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Venture Capital TV
2020 OrthoChallenge Winner Interview for Self-Leveling Walker
July 2020
Venture Capital TV’s Showcase features promising companies looking for start-up and growth capital in specific market sectors. Venture Capital Sector Showcase – MedTech highlights a full spectrum of businesses in the medical technology arena ranging from health IT, bio-informatics, Health AI to patient-empowering and information-leveraging (PI) technologies and regenerative medicine. Listen to the interview...
Also in: Orthopaedic Research and Education Foundation (OREF) TV

New, Quick Test For Sickle Cell Disease Comes Online
19 Jun 2020
Case Western Reserve University researchers are behind a promising new tool for detecting a serious blood disorder. Early detection is key in fighting sickle cell disease, an inherited blood abnormality that can be fatal. The new test, called Gazelle, makes a quick diagnosis using artificial intelligence and microchip technology. CWRU researcher Dr. Umut Gurkan led studies into the technology in 2014 and said the key is its accessibility. Listen to the interview...

The daily
A new weapon in the fight against sickle cell disease
18 Jun 2020
A technology developed initially at Case Western Reserve University is behind the global launch this week by a Portland, Oregon, company of a new, faster and low-cost diagnostic test for sickle cell disease (SCD). The announcement by Hemex Health comes just in advance of World Sickle Cell Disease Awareness Day on Friday, June 19.
“This is a special day for me and for my lab members,” said Umut Gurkan, the Warren E. Rupp Associate Professor in the Department of Mechanical and Aerospace Engineering in the Case School of Engineering. Gurkan leads a university team that also recently was awarded up to $3.7 million from the NHLBI to assess emerging genome editing-based therapies being tested for SCD at leading U.S. research universities and hospitals. Read more...

'Optimized for the underserved': A new diagnostic test built for low-income settings
17 Jun 2020
A new portable diagnostic platform could change the way sickle cell disease is tested, and offer a model for developing point of care tests for a range of diseases in low-resource settings. ... The portable diagnostic platform combines proprietary microchip electrophoresis technology, which is a miniaturized version of the traditional blood test, with artificial intelligence. Gazelle also includes a test for malaria, and the Hemex Health team is working to develop tests for anemia and COVID-19. ... Before Hemex Health started the development of Gazelle, with technology licensed from Case Western Reserve University in Cleveland, Ohio, it conducted a multistate research project in India, and collected ... Read more...

VA Research Currents
VA scientists testing new technology to absorb moisture, increase comfort with prostheses
11 Jun 2020
The Advanced Platform Technology Center at the Louis Stokes Cleveland VA Medical Center is highly regarded for developing innovative technologies that serve Veterans with sensory, motor, or cognitive deficits, as well as limb loss. ... One of the ongoing projects is aimed at developing a material to better absorb and channel the sweat that can build up inside the socket liner of a prosthesis. Read more...

PR Newswire
"For Such A Time As This -- OrthoChallenge" Winners Announced
10 Jun 2020
Six innovative ideas to help patients with musculoskeletal conditions have been selected to win the 'For Such A Time As This – OrthoChallenge.' These novel products have the potential to help orthopedic patients during and after the COVID-19 pandemic and reduce their risks during an operative procedure. Ronald Triolo, Stephanie Bailey, and Frank Zitko for the "Self-Leveling Walker for Safe Stair and Ramp Mobility," which adjusts... Read more...
Also in: Orthopedics This WeekBoneZone, Medical Products Outsourcing (MPO) Magazine

CU Boulder Today
Now closer to reality: Prosthetics that can feel
21 May 2020
Through an effort led by Case Western Reserve University and the VA, Segil and his colleagues have used a unique “neural interface” to give a small number of amputees back the sense of touch in their missing fingers. In a new study, published this month in the journal Scientific Reports, the team demonstrated just how effective this sensory restoration technology can be—helping one amputee to feel his hand adopt a series of postures, such as ... Read more...

Cleveland 19 News
How vulnerable are dams in Northeast Ohio?
20 May 2020
Experts described the flooding in Midland, Mich. as a 500-year event, caused by two dams in the area that failed.... Dr. Bill Yu is a civil engineering professor at Case Western Reserve University. He says there are around 1,400 “high hazard” dams in Ohio, 40 to 50 of those are in Northeast Ohio, but there are different types of dams built for different purposes. Read more...

The daily
Biomedical engineering researchers write paper evaluating lower-limb sensory neuroprosthesis
15 May 2020
Ronald Triolo, professor of biomedical engineering, Hamid Charkhkar, senior research associate in the biomedical engineering department, and Breanne Christie, postdoctoral scholar in biomedical engineering, published a paper evaluating their lower-limb sensory neuroprosthesis. The paper, published in Nature’s Scientific Reports, evaluated the impact of the neuroprosthesis on maintaining balance. Read more...

The daily
Engineering’s Umut Gurkan co-writes paper featured on cover of The Royal Society of Chemistry’s Analyst
15 May 2020
Umut Gurkan, the Warren E. Rupp Associate Professor in the Department of Mechanical and Aerospace Engineering, co-wrote a paper with an international team of clinicians and researchers that was featured on the cover of The Royal Society of Chemistry’s Analyst. The paper describes HemeChip, a microchip electrophoresis platform used for identifying common hemoglobin variants. Read more...

Popular Mechanics
At the Bionic Olympics, Engineers and Athletes Make Miracles
27 Apr 2020
Popular Mechanics released an article about Mark Daniel, a pilot from the 2016 Cybathlon who competed in the Exoskeleton Race. At the event, he was impressed with the performance capabilities of the pilot from our Center's Team Cleveland, led by Dr. Ronald Triolo, and spoke with him at length about his implanted neurostimulation technology. As a result, Mark is now a participant in Dr. Triolo's standing and transfer research project. Read about his journey!

APT Center announcement
New NIH Funding and Clinical Trials Start Soon in Effort to Cure SCD
17 Apr 2020
Congratulations to Umut Gurkan, PhD for receiving $3.7M in funding from the National Heart, Lung, and Blood Institute (NHLBI) to assess emerging genome-editing based therapies being tested for curing sickle cell disease (SCD). Dr. Gurkan and his team have developed... Read more... 

Crain's Cleveland Business
CWRU helps lead research efforts on potential cure for sickle cell disease
15 Apr 2020
Case Western Reserve University has received significant funding from the National Heart, Lung and Blood Institute to support work toward a potential cure for sickle cell disease. The institute's Cure Sickle Cell Initiative supports collaborative research to speed up the development of genetic therapies within five to 10 years, according to a post on the university's The Daily site. Umut Gurkan, the Warren E. Rupp Associate Professor in the School of Engineering, is leading a team "that has developed micro-engineered tools to assess blood samples from patients before and after gene therapy treatment" for sickle cell disease... Read more... 

APT Center announcement
Benchmark First-In-Human Trials May Expand the Field of Urodynamics
10 Apr 2020
First-in-human clinical trials are underway for the UroMonitor, a wireless catheter-free intravesical pressure sensor that enables bladder monitoring - a FitBit for the bladder. Margot Damaser, PhD and Steve Majerus, PhD jointly create and oversee development of novel wireless catheter-free monitoring devices within the APT Center. Read more...

The daily
Reaching toward a cure for sickle cell disease
03 Apr 2020
Umut Gurkan, the Warren E. Rupp Associate Professor in the Department of Mechanical and Aerospace Engineering in the Case School of Engineering, leads a university team that has developed micro-engineered tools to assess blood samples from patients before and after gene therapy treatment for SCD. “The big-picture potential here is to test whether this is dream or reality when it comes to gene therapy curing sickle cell,” Gurkan said. Read more...

APT Center announcement
ClotChip Earns FDA Breakthrough Device Designation
27 Mar 2020
XaTek Inc. has received Breakthrough Device designation from the U.S. Food and Drug Administration (FDA) for its in-development ClotChip, marking a significant and distinguishing step in advancing the company's life-changing portable blood-clotting sensor toward commercialization. The team of researchers involved in the development, testing, and clinical trials of ClotChip include the following APT Center Investigators Pedram Mohseni, PhD; Michael Suster, PhD; Evi Stavrou, MD; Umut Gurkan, PhD. Read more...

The daily

Engineering’s Janet Gbur elected treasurer of Microscopy Society of America
12 Mar 2020
Janet Gbur, research associate in materials science and engineering, was elected to a two-year term as treasurer of the Leadership Council of the Microscopy Society of America during the group’s leadership elections in December. Read more...
Original press release: Microscopy Society of America

Crain's Cleveland Business
XaTek's ClotChip Earns FDA's Breakthrough Device Designation
03 Mar 2020
XaTek Inc. today announced that the company has received Breakthrough Device designation from the U.S. Food and Drug Administration (FDA) for its in-development ClotChip, marking a significant and distinguishing step in advancing the company's life-changing portable blood-clotting sensor toward commercialization. The FDA Breakthrough Devices Program was created in 2018 to expedite the development, assessment and review of technologies that "provide for more effective treatment or diagnosis of life-threatening or irreversibly debilitating human disease or conditions" over existing approved products. Read more...
XaTek Inc., PRNewswire, the Daily

APT Center announcement
Translation Builder: APT Center Newsletter, February 2020
27 Feb 2020

YouTube: VICE News
How Bionic Limbs Are Changing Lives
24 Feb 2020 (released on YouTube)
A bionic revolution is brewing, as recent advancements in bioengineering have brought about scientific breakthroughs in rehabilitation for people with disabilities. The most cutting edge research is happening inside the human brain, where implanted technology allows people to communicate directly with computers, using their thoughts. VICE's Wilbert L. Cooper travels to Zurich to see the first-ever bionic Olympics (aka Cybathlon, in 2016) and discovers a host of technologies that are expanding what it means to be human. APT Center's Team Cleveland won the gold medal in the electrical stimulation bike race.

APT Center announcement
New Funding for the Neuro-Mechanical Exoskeleton
20 Feb 2020
The simple act of walking for stroke survivors is often compromised by muscle weakness, lack of joint coordination, or increased tone which causes toe dragging, poor stability, and increased risk of falls. This funding was awarded to Principal Investigators Rudi Kobetic, MSBE and Ronald Triolo, PhD... Read more... 

APT Center announcement
VA Technology Transfer Office BRAVE Development Fund Awards
18 Feb 2020
Congratulations to Drs. Bogie and Triolo who have received VA Technology Transfer Office BRAVE Development Fund grants. Read more...

U.S. Medicine
Balance Disorder Expert Works to Fill Growing Medical Need for Veterans
11 Feb 2020
Aasef Shaikh, MD, PhD, grew up in India as the son of two ENT surgeons, which he credits for his early interest in understanding the system that helps humans keep their balance. After finishing medical school, he immigrated to the United States to pursue a PhD in neuroscience, where his fascination with human balance only grew. Read more...

The daily
Winners of the SOURCE Intersections poster competition announced
23 Jan 2020
Support of Undergraduate Research and Creative Endeavors (SOURCE) hosts Intersections, a poster session where undergraduate students present their research and creative projects. The event, held each semester, is an opportunity for the Case Western Reserve community to learn about the array of academic work being done by students across campus. At the fall semester Intersections on Dec. 6, 2019, 10 student projects earned awards. First place in Engineering: Alan Dogan—“Selective PEGylation of Sirolimus for Enhanced Stability and Additional Functionalization,” mentored by Horst von Recum, Department of Biomedical Engineering. Read more...

ASM International
Women In Engineering: Janet Gbur
21 Jan 2020
This profile series introduces leading materials scientists from around the world who happen to be females. Here we speak with Janet Gbur,research associate at Case Western Reserve University, Cleveland, investigator at the Louis Stokes VA Medical Center, Cleveland, and adjunct faculty at Youngstown State University, Youngstown, Ohio.

The daily
Faculty researchers receive two National Science Foundation awards
03 Jan 2020
Case Western Reserve University researchers recently received two National Science Foundation awards. Burcu Gurkan also is the principal investigator on a second grant along with collaborators Umut Gurkan, the Warren E. Rupp Associate Professor in the Department of Mechanical and Aerospace Engineering (co-principal investigator)... The second grant is for work titled “Instrument Development: Multiplex Sensory Interfaces Between Photonic Nanostructures and Thin Film Ionic Liquids.” The researchers received a grant for $450,000 for three years. Read more...

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